Electrochemical multicomponent reaction toward vicinal sulfenyltetrazolation of unactivated alkenes

Abstract

1,3-Dipole cycloaddition reaction represents the most straightforward method for the preparation of tetrazoles. However, this approach commonly requires the use of toxic isocyanides at evaluated temperatures, which raises considerable safety and environmental concerns. Herein we demonstrate that our recently developed electrochemical multicomponent reaction (e-MCR) is a green and sustainable solution to the sulfenyltetrazolation of unactivated alkenes with the readily available thiols azidotrimethylsilane, and acetonitrile, which are inaccessible with the existing methods.