Application trends of hydrogen-generating nanomaterials for the treatment of ROS-related diseases

Abstract

Reactive Oxygen Species (ROS) play essential roles in both physiological and pathological processes. Under physiological conditions, the appropriate amount of ROS plays an important role in signaling and regulation in cells. However, too much ROS can lead to many health problems, including inflammation, cancer, wound healing, neurodegenerative diseases (such as Parkinson's disease and Alzheimer's disease), and autoimmune diseases, and oxidative stress from excess ROS is also one of the most critical factors in the pathogenesis of cardiovascular and metabolic diseases such as atherosclerosis. Hydrogen gas effectively removes ROS from the body due to its good antioxidant properties, and hydrogen therapy has become a promising gas therapy strategy due to its inherent safety and stability. The combination of nanomaterials can achieve targeted delivery and effective accumulation of hydrogen, which has some ameliorating effects on diseases. Herein, we summarized the use of hydrogen-producing nanomaterials for the treatment of ROS-related diseases, and talked about the prospects for the treatment of other ROS-induced disease models such as acute kidney injury.