Themed collection Journal of Materials Chemistry B HOT Papers

For biosensors based on DNA or aptamer probes and nanomaterials, aside from studying DNA adsorption and desorption, it is also important to examine the effect of target adsorption and other possible surface interaction mechanisms.

The properties of biocatalysis can be tuned by encapsulation of enzymes inside protein cages, which alters enzyme behaviors, substrate access and product release, and efficiency of cascade reactions.

Nanomaterial-based cancer therapy faces significant limitations due to the complex nature of the tumor microenvironment (TME).

In a game of humans versus pathogenic microbes, will MicroRNAs be a key weapon for humans to defeat bacterial infections?

Photodynamic therapy (PDT) with an oxygen-dependent character is a noninvasive therapeutic method for cancer treatment.

This review provides an overview of the latest research progress in mRNA structural optimization strategies and their delivery systems, and discusses key considerations for their future clinical use.

The binding of stem cells with a peptide-immobilized material surface, where several peptides are designed and conjugated on the material with multiple reactions, activates several signaling pathways that determine the stem cell fate.

Five calixarene-based cryoprotectants with ice recrystallization inhibition activity and a cellular cryopreservation effect were studied, which provided a supramolecular principle for the development of novel cryoprotectants.

This study proposes a straightforward method to enhance the adhesion, flexibility, and stretchability of polyacrylamide hydrogels through the incorporation of tris, positioning it as a promising matrix for skin-attachable applications.

This study provides proof of charge complementarity-based inclusion complex formation between an engineered protein nanocage and an otherwise degradation-prone cargo protein in live bacterial cells.

A facile redox-controlled sequential delivery of hydrophilic and hydrophobic drugs was achieved by multiblock copolymer vesicles containing disulfide as the only kind of responsive linkage.

Protein-based adsorber materials with defined morphology for the removal of uremic toxins.

The multi-functional nanoparticle HN@Cu-MOF integrates PDT/CDT/GT, leading to a significant enhancement in GSH consumption and an elevation in ROS production, initiating the sensitization to PDT and cell apoptosis in the treatment of tumors.

Tea polyphenol self-assembled nanocarriers synergistically enhance dexamethasone treatment of rheumatoid arthritis through antioxidant and inflammation targeting.

A coordination–crystallization approach was developed to prepare platinum nanoparticle-anchored metal–organic complexes, which show excellent sonodynamic therapy for tumors.

Bacterial double-layered membrane vesicles were used as an immune adjuvant to develop a biomimetic phototherapeutic nanoagent, which could exert synergistic effects of PTT/PDT and immune stimulation for OSCC comprehensive treatment.

A nontoxic NIR-CDs nanoprobe exhibits dual responses to detect OTC in cell imaging (NIH3T3, HeLa) and effectively detects OTC in milk, honey, and lake water.

The MXene/ionic liquid synergistic network was constructed in this work to solve the problem of poor mechanical properties of ionogel at high ionic liquid content. And, the ionogel was applied to human-motion detection.

A CT-responsive hydrogel uses the CT responsiveness of calcium ions to construct an accurately matched CT-equivalent phantom and endow it with good stability in order to obtain reliable features in the field of radiology.

By combining polyA-mediated spherical nucleic acids with toehold mediated strand displacement reaction, a fuel-initiated DNA molecular machine has been constructed for sensitively and selectively detecting microRNA-22 in fetal bovine serum.

A salt-gradient aptamer-assisted nanopore strategy detects SARS-COVID-2 nucleocapsid protein with distinctive blockades. The molecular mechanism of protein–aptamer interaction was studied using an α-hemolysin nanopore to validate effectiveness.

A curcumin-based photosensitizer, CN, can specifically target lipid droplets (LDs) and the endoplasmic reticulum (ER) simultaneously, which can enhance PDT effect of CN due to apoptosis by destroying the ER and ferroptosis by oxidizing PUFAs in LDs.

A nanoplatform with functions of the Fenton-reaction, self-supplied H₂O₂, GSH-elimination, H₂S generation and DOX delivery for synergistic multi-enhanced CDT/chemotherapy/H₂S cancer therapy.

The reasonable structure of aza-BODIPY renders it as an efficient photothermal reagent for photothermal therapy.

An all-in-one bionanoprobe was developed for self-driven immune checkpoint blockade and spatiotemporal-sensitive immune response monitoring in heterogeneous acute myeloid leukemia cells.

This paper presents the successful development of ultrathin (atomic thickness), large-scale (up to millimeter size) and microporous suspended graphene and verifies its promising potential as membrane for cell culture models.

We engineer DTN-corbelled click chemistry to trigger a HCR assembling a large-scale of nanozymes for ratiometric fluorescence detection of DNA Dam. The biosensor displayed a low detection limit of 0.001 U mL⁻¹ for Dam MTase and was effective in real sample and methylation inhibitor screenings.

A new class of D–π–A teraryl-based AIEgen 6a was designed and synthesized for selective staining of intracellular lipid droplets.

The nanoplatform of ASH was constructed for synergetic chemotherapy/photothermal/radiation therapy to stimulate the immunogenic cell death process for breast cancer treatment.

The membrane-mediated magneto-stress-electric-coupled-sensitization biosensor (MSEC-MMB) was developed with a LOD of 24 pg mL⁻¹ for HSA. The biosensor showed a high sensitivity and practicality, providing a platform for early nephropathy diagnosis.

A new type of nanodrug with curcumin derivatives as the crosslinker, which can maintain stability in blood circulation and actively target breast cancer tumors.

Visualizing a LAP change in cancer cells and normal cells and guiding surgical resection of liver cancer by engineering an activated near-infrared fluorescent probe with high sensitivity and selectivity.

Schematic representation of 3D Printed PCL/PEG artificial bile duct fabrication and in vivo promotion of biliary regeneration.

NanoMUV-2 stores high payloads of Paclitaxel and increases its anticancer selectivity.

The CoOOH-IR780@BSA (CoIRB) drug delivery nanoplatform allows for a combined approach of PTT/PDT/CDT against colon tumors, resulting in enhanced therapeutic efficacy through effective consumption of GSH and H₂S.

Magnetic mesoporous silica nanoparticles with multi-functions are proposed for synergistic chemoimmunotherapy and magnetic field-guided tumor-targeting therapeutics.

A novel dual-responsive core–shell nanoparticle (NP) system was successfully constructed for cancer treatment with synergistic drug/gene therapies.

In this study, a fluoropolymer PF was prepared as antigen protein vector and immune adjuvant, which could be applied to fabricate nanovaccine with OVA to boost immunotherapy in vivo.

Within hydrogen-bonded organic frameworks (HOFs), the stabilized charge transfer cocrystals, named TQC@PFC-1, exhibit high photothermal conversion efficiency in the NIR II region for photothermal therapy in both in vitro and in vivo settings.

With high NIR light absorption and sharp nanosheet edges, TiO NSs have excellent mechanical and photothermal bactericidal properties, which is the only report to date on titanium-based oxides in wound healing.

Solvatochromic crystal induced emission sensors visualize and quantify proteomeaggregation in buffer, cell lines and clinic tissues.

Membrane fouling induces catastrophic loss of separation performance and seriously restricts the applications of reverse osmosis (RO) membranes.

In this work, we propose and demonstrate a repurposing strategy for an antimicrobial peptide, aurein, which can simultaneously modulate hIAPP aggregation and inhibit microbial infection.

A new, safe and effective strategy for biofilm eradication and tooth whitening is reported using the piezo-photocatalytic effect of g-C₃N_4−x/Bi₂O_3−y heterostructures.

Nanoparticles from BODIPY photosensitizers decorated with chiral amino acids have been prepared and exhibit different photodynamic activities.

By incorporating photothermal dopamine domains into hyaluronic acid chains, a biomimetic photothermal hydrogel with matrix-mediated homogeneous thermal stimulus is obtained for promoting neural differentiation of BMSCs under remote light stimulus.

An integrated iron-porphyrin-MOF-based nanozyme composite named HGPF was constructed for the intracellular glucose-initiated catalytic oxidation cascades and light-enhanced generation of ROS, synergistically amplifying cellular oxidative stress.

A microneedle patch has been developed to bridge the gap between H₂O₂ self-supplying chemodynamic therapy and photothermal therapy, resulting in enhanced therapy of cutaneous squamous cell carcinoma.

The DOX@7FZ was able to enhance the ROS level in cancer cells via a synergistic effect between apoptosis/ferroptosis synergism.

Long-gap peripheral nerve injury remains a major challenge in regenerative medicine and results in permanent sensory and motor dysfunction.

To address the issue of infection in interventional biomedical implants, we reported cost-effective cationic polypeptoids modified polyurethane (PU) films (PU-PNBM, PU-PNBE, PU-PNBB) to create physical-biological synergistic antibacterial surfaces.

A PAI probe (Au@PDA-WL NPs) was successfully prepared for targeting and monitoring the early degeneration of articular cartilage. And the catechol structure in the PDA shell could eliminate ROS to effectively delay the development of osteoarthrosis.

A unique optical nanoprobe, constructed based on persistent luminescence nanoparticles, can emit sufficient NIR light after ceasing excitation and is introduced to track the nanoparticles distribution in plants by high-sensitivity in vivo imaging.

A core–shell MN platform with controllable CO photoproduction was fabricated. Effervescent design enabled efficient CO generation and enhanced drug permeation. The CO-sensitized chemotherapeutic MNs had great curative efficiency for melanoma.

An interpenetrating network design was used to enhance the toughness of PEG-based hydrogel coatings to resist damage during surgical handling.

The TA-BSA@CuS with CuO doped heterostructure prepared by simulating biomineralization, which has good photothermal properties and biocompatibility, while NIR-II irradiation can enhance the free radical scavenging ability and antibacterial properties of TA-BSA@CuS.

Hydrophilic magnetic host–guest Ti–phenolic networks (mTiCD@AG) were successfully prepared for the simultaneous enrichment of glycopeptides/phosphopeptides.

A PrS/pDNA/RAPA nanocomposite coating of a drug-coated balloon inhibits neointimal hyperplasia and facilitates endothelial regeneration after balloon-induced vascular injuries.

Host–guest interactions were used to direct the interfacial self-assembly of quantum dots into a nanosystem for synergistic chemo-photodynamic therapy against cancer.

A two-photon excited fluorescent probe CMB-1 has been rationally developed based on a new sensing mechanism for the detection and regeneration of formaldehyde in living cells with minimal influence on its native homeostasis and local concentration.

In brief, CNFs can make the composite membrane hydrophobic with superior extension, and CNCs can make the composite membrane hydrophilic and enhance its strength.

Vinyl sulfone (VS) functionalization – An innovative conjugation approach for preparation of variable new antigen receptor (VNAR) targeted polymeric nanoparticles.

The combination of ionizable lipids bearing alkyl chains and fluorinated alkyl chains improves the cellular uptake and mRNA expression of lipid nanoparticles.

A novel controllable strategy to construct a spatiotemporal dynamical hydrogel based on an M1-to-M2 immune environment for the treatment of cutaneous wounds.

A modular hepatitis B virus-like particle delivery platform enables enhanced uptake and toxicity in cancer cells.

Thiol-ligand exchange to form either 1D luminescent or 2D non-emissive Ag(I)-based coordination polymers.

The enhanced osteogenic properties activated by micro/nano-structures could be memorized and continue to play a role even after the removal of micro/nano-structures.

Multifunctional black phosphorus (BP) hydrogel nerve growth conduits (NGCs) loaded with neuregulin 1 (Nrg1) were fabricated to support peripheral-nerve regeneration.

Nanotechnology is an effective way to stimulate the yield potential of crops.

Scheme of the study of drug release and diffusion behavior of a therapeutic microneedle (T-MN) via a SERS detection microneedle (D-MN) in dermal interstitial fluid (ISF).