Issue 23, 2012
From the journal:

RSC Advances

A polymeric membrane permeabilizer displaying densely packed arrays of crown ether lateral substituents†

Ming Liu,a   Anna Bertova,b   Nicolas Illy,a   Blandine Brissault,a   Jacques Penelle,a   Karol Ondriasb  and  Valessa Barbier*a  

* Corresponding authors

a Institut de Chimie et des Matériaux Paris-Est (ICMPE), CNRS and Université Paris-Est, 2-8 rue Henri Dunant, 94320 Thiais, France
E-mail: barbier@icmpe.cnrs.fr
Fax: +33 (0)1 49 78 12 08
Tel: +33 (0)1 49 78 11 94

b Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlarska 5, 833 34 Bratislava, Slovak Republic
E-mail: karol.ondrias@savba.sk
Fax: ++421 2 54773666
Tel: ++421 2 54774102

Abstract

We report the design, synthesis and evaluation of a novel macromolecular membrane permeabilizer displaying geminally substituted crown-ethers (18-crown-6) on every third carbon alongside the backbone. The polymer has a rather high affinity with potassium as well as permeabilization properties towards K+, Na+ and Ca2+, including single-channel behavior.

Graphical abstract: A polymeric membrane permeabilizer displaying densely packed arrays of crown ether lateral substituents

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Article information

DOI
https://doi.org/10.1039/C2RA20548C
Article type
Communication
Submitted
26 Mar 2012
Accepted
11 Jul 2012
First published
20 Aug 2012

RSC Adv., 2012,2, 8606-8609

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A polymeric membrane permeabilizer displaying densely packed arrays of crown ether lateral substituents

M. Liu, A. Bertova, N. Illy, B. Brissault, J. Penelle, K. Ondrias and V. Barbier, RSC Adv., 2012, 2, 8606 DOI: 10.1039/C2RA20548C

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