Issue 87, 2014
From the journal:

Chemical Communications

Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells†

Eun Hye Jeong,a   Ji Hyun Ryu,b   Hansaem Jeong,a   Bora Jang,a   Ho Yeon Lee,a   Seonki Hong,b   Haeshin Leeb  and  Hyukjin Lee*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea
E-mail: hyukjin@ewha.ac.kr

b Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea

Abstract

Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus.

Graphical abstract: Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells

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Article information

DOI
https://doi.org/10.1039/C4CC07155G
Article type
Communication
Submitted
11 Sep 2014
Accepted
12 Sep 2014
First published
12 Sep 2014

Chem. Commun., 2014,50, 13388-13390

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Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells

E. H. Jeong, J. H. Ryu, H. Jeong, B. Jang, H. Y. Lee, S. Hong, H. Lee and H. Lee, Chem. Commun., 2014, 50, 13388 DOI: 10.1039/C4CC07155G

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