Issue 73, 2015
From the journal:

Chemical Communications

Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants†

Alberto Fernández-Tejada,*a   Derek S. Tan*ab  and  David Y. Gin‡ab  

* Corresponding authors

a Chemical Biology Program, Memorial Sloan Kettering Cancer Center, 1 275 York Avenue, New York, NY 10065, USA
E-mail: alberto.fernandezt@gmail.com

b Tri-Institutional Research Program, Memorial Sloan Kettering Cancer Center, 1 275 York Avenue, New York, NY 10065, USA
E-mail: tand@mskcc.org

Abstract

We describe a new, versatile synthetic approach to Quillaja saponin variants based on the natural product immunoadjuvant QS-21. This modular, divergent strategy provides efficient access to linear oligosaccharide domain variants with modified sugars and regiochemistries. This new synthetic approach opens the door to the rapid generation of diverse analogues to identify novel saponin adjuvants with improved synthetic accessibility.

Graphical abstract: Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants

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Article information

DOI
https://doi.org/10.1039/C5CC05244K
Article type
Communication
Submitted
25 Jun 2015
Accepted
27 Jul 2015
First published
05 Aug 2015

Chem. Commun., 2015,51, 13949-13952

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Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants

A. Fernández-Tejada, D. S. Tan and D. Y. Gin, Chem. Commun., 2015, 51, 13949 DOI: 10.1039/C5CC05244K

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