Issue 78, 2015
From the journal:

Chemical Communications

Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues†

Camilo F. Martinez-Farinaa  and  David L. Jakeman*b  

* Corresponding authors

a Department of Chemistry, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada

b College of Pharmacy, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada
E-mail: david.jakeman@dal.ca

Abstract

We report the production, isolation, and characterization of jadomycins with seven-, nine-, and ten-membered E-rings, all of which are unique natural product ring scaffolds. This significantly expands the scope of a non-enzymatic biosynthetic step in jadomycin biosynthesis in order to produce novel natural products.

Graphical abstract: Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues

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DOI
https://doi.org/10.1039/C5CC05571G
Article type
Communication
Submitted
07 Jul 2015
Accepted
12 Aug 2015
First published
12 Aug 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 14617-14619

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Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues

C. F. Martinez-Farina and D. L. Jakeman, Chem. Commun., 2015, 51, 14617 DOI: 10.1039/C5CC05571G

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