Issue 22, 2015
From the journal:

Organic & Biomolecular Chemistry

A mild and facile synthesis of polyfunctionalized pyridines: merging three-component cyclization and aerobic oxidation by amine/metal catalysts†

Chunyin Zhu,*a   Benwei Bi,a   Ya Ding,a   Te Zhanga  and  Qiu-Yun Chena  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. China
E-mail: zhucycn@gmail.com

Abstract

A mild and facile synthesis of polyfunctionalized pyridines from NH4OAc, β,γ-unsaturated α-ketoesters, and ketones/aldehydes has been reported through tandem three-component cyclization and aerobic oxidation using the combination of amine and metal catalysts. The synthetic value of the developed methodology was demonstrated by a gram-scale reaction and a wide range of substrates including naturally occurring citronellal.

Graphical abstract: A mild and facile synthesis of polyfunctionalized pyridines: merging three-component cyclization and aerobic oxidation by amine/metal catalysts

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Article information

DOI
https://doi.org/10.1039/C5OB00630A
Article type
Paper
Submitted
31 Mar 2015
Accepted
24 Apr 2015
First published
28 Apr 2015

Org. Biomol. Chem., 2015,13, 6278-6285

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A mild and facile synthesis of polyfunctionalized pyridines: merging three-component cyclization and aerobic oxidation by amine/metal catalysts

C. Zhu, B. Bi, Y. Ding, T. Zhang and Q. Chen, Org. Biomol. Chem., 2015, 13, 6278 DOI: 10.1039/C5OB00630A

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