Issue 49, 2015
From the journal:

RSC Advances

Preclinical appraisal of terbutaline analogues in precipitation of autism spectrum disorder

Neha Sharma,a   Swetlana Gautam,a   Uma Devi,b   Manjari Singh,a   Jitendra K. Rawat,a   Nikunj Sethi,c   Shubhini A. Sarafa  and  Gaurav Kaithwas*a  

* Corresponding authors

a Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226 025, U.P., India
E-mail: gauravpharm@hotmail.com
Tel: +91-9670204349

b Department of Pharmaceutical Sciences, Faculty of Health Medical Sciences Indigenous and Alternative Medicine, SHIATS-Deemed to be University Formerly Allahabad Agricultural Institute, Naini, Allahabad, U.P., India

c Division of Toxicology, CSIR-Central Drug Research Institute, Lucknow-226 031, U.P., India

Abstract

Terbutaline is a β2 agonist used in the clinical management of asthma and as a tocolytic agent during pregnancy. In the recent past, the preterm use of terbutaline has been shown to hasten autistic-like symptoms in offsprings. For this reason, the present study was carried out to understand the effects of pharmacological analogues of terbutaline (salbutamol, salmeterol and montelukast) in the progression of ASDs in experimental animals. Pregnant rats were treated with salbutamol (10 mg kg−1, sc), salmeterol (10 μg kg−1, sc) and montelukast (10 mg kg−1, sc) and the offsprings were scrutinized for behavioral, biochemical, neuro-inflammatory and histopathological changes. The offsprings from the rats treated with salbutamol and montelukast were determined to be closely associated with various symptoms of ASDs.

Graphical abstract: Preclinical appraisal of terbutaline analogues in precipitation of autism spectrum disorder

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Article information

DOI
https://doi.org/10.1039/C5RA04213E
Article type
Communication
Submitted
10 Mar 2015
Accepted
13 Apr 2015
First published
13 Apr 2015

RSC Adv., 2015,5, 39003-39011

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Preclinical appraisal of terbutaline analogues in precipitation of autism spectrum disorder

N. Sharma, S. Gautam, U. Devi, M. Singh, J. K. Rawat, N. Sethi, S. A. Saraf and G. Kaithwas, RSC Adv., 2015, 5, 39003 DOI: 10.1039/C5RA04213E

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