Issue 62, 2016
From the journal:

Chemical Communications

Beyond “turn-on” readout: from zero background to signal amplification by combination of magnetic separation and plasmon enhanced fluorescence†

Suqin Gonga  and  Yunsheng Xia*a  

* Corresponding authors

a Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, China
E-mail: xiayuns@mail.ahnu.edu.cn

Abstract

By magnetic separation and subsequent plasmon enhanced fluorescence, an assay platform with a signal output from completely “zero” background to fluorescence amplification is achieved, using quantum dots as reporters. So, it well breaks through the conventional “turn-on” strategy in both lower and upper limits. The sensitivity for hyaluronidase sensing is enhanced 104–106 times as compared with previous fluorescence methods.

Graphical abstract: Beyond “turn-on” readout: from zero background to signal amplification by combination of magnetic separation and plasmon enhanced fluorescence

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Article information

DOI
https://doi.org/10.1039/C6CC03850F
Article type
Communication
Submitted
08 May 2016
Accepted
29 Jun 2016
First published
29 Jun 2016

Chem. Commun., 2016,52, 9660-9663

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Beyond “turn-on” readout: from zero background to signal amplification by combination of magnetic separation and plasmon enhanced fluorescence

S. Gong and Y. Xia, Chem. Commun., 2016, 52, 9660 DOI: 10.1039/C6CC03850F

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