Issue 1, 2017
From the journal:

RSC Advances

Self-immolative polymers as novel pH-responsive gate keepers for drug delivery†

M. Gisbert-Garzaran, ORCID logo ab   D. Lozano, ORCID logo ab   M. Vallet-Regí ORCID logo *ab  and  M. Manzano ORCID logo *ab  

* Corresponding authors

a Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia. Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i + 12, Plaza de Ramón y Cajal s/n, E-28040 Madrid, Spain
E-mail: vallet@ucm.es, mmanzano@ucm.es

b Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
Fax: +34 913941786
Tel: +34 913941861

Abstract

A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new material a promising candidate for future applications in cancer treatment.

Graphical abstract: Self-immolative polymers as novel pH-responsive gate keepers for drug delivery

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DOI
https://doi.org/10.1039/C6RA26771H
Article type
Communication
Submitted
14 Nov 2016
Accepted
07 Dec 2016
First published
07 Dec 2016
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 132-136

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Self-immolative polymers as novel pH-responsive gate keepers for drug delivery

M. Gisbert-Garzaran, D. Lozano, M. Vallet-Regí and M. Manzano, RSC Adv., 2017, 7, 132 DOI: 10.1039/C6RA26771H

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