Menaquinone biosynthesis inhibition: a review of advancements toward a new antibiotic mechanism
Abstract
Menaquinone is essential in electron transport and ATP generation in all Gram-positive, and anaerobically respiring Gram-negative bacteria. By inhibiting menaquinone production in target organisms, bactericidal action can be achieved irrespective of the organisms' growth phase. This pathway is absent in human cells, as menaquinone is obtained only through the diet. This paper provides a succinct review of major advancements, where present, at all enzymatic steps of the biosynthetic pathway of menaquinone. Structure–activity relationships are evaluated, as well as results translating these relationships to growth inhibition studies.
- This article is part of the themed collections: 2018 Open Access Week Collection and 2017 and 2018 RSC Advances Reviews from Around the World
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