Issue 5, 2019
From the journal:

Chemical Communications

Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity†

Takanori Matsumaru,*ab   Risa Ikeno,a   Yusuke Shuchi,a   Toshiki Iwamatsu,a   Takashi Tadokoro,a   Sho Yamasaki,c   Yukari Fujimoto, ORCID logo b   Atsushi Furukawa ORCID logo a  and  Katsumi Maenaka ORCID logo *a  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan
E-mail: maenaka@pharm.hokudai.ac.jp

b Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan
E-mail: matsumaru@keio.chem.ac.jp

c Department of Molecular Immunology Research Institute for Microbial Diseases, and Laboratory for Molecular Immunology, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan

Abstract

Mincle, expressed in activated phagocytes, recognizes the lipid ligand to activate the innate immune system. We have synthesized glycerol derivatives possessing simple alkyl chains or aromatic rings and elucidated their structure–activity relationships using a Mincle-mediated signaling assay. The activity depends on the length of the simple acyl chains of the glycerol derivatives.

Graphical abstract: Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity

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Article information

DOI
https://doi.org/10.1039/C8CC07322H
Article type
Communication
Submitted
09 Sep 2018
Accepted
08 Dec 2018
First published
10 Dec 2018

Chem. Commun., 2019,55, 711-714

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Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity

T. Matsumaru, R. Ikeno, Y. Shuchi, T. Iwamatsu, T. Tadokoro, S. Yamasaki, Y. Fujimoto, A. Furukawa and K. Maenaka, Chem. Commun., 2019, 55, 711 DOI: 10.1039/C8CC07322H

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