Issue 93, 2018
From the journal:

Chemical Communications

Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration†

Cheng Wang, ORCID logo a   Xuerong Liu,a   Shaoqing Chen,a   Fuqiang Hu, ORCID logo a   Jihong Sun*b  and  Hong Yuan ORCID logo *a  

* Corresponding authors

a College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, China
E-mail: yuanhong70@zju.edu.cn

b Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 Qingchun East Road, Hangzhou, China
E-mail: braversun@sina.com

Abstract

A facile solvent diffusion method was developed to prepare phospholipid–amorphous calcium carbonate (ACC) hybrid nanoparticles via a one-pot approach. The hybrid nanoparticles can specifically realize water-responsive burst drug release in cancer cells and potentiate drug penetration into deep tumor tissues for advanced cancer therapy.

Graphical abstract: Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration

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Article information

DOI
https://doi.org/10.1039/C8CC07694D
Article type
Communication
Submitted
25 Sep 2018
Accepted
24 Oct 2018
First published
25 Oct 2018

Chem. Commun., 2018,54, 13080-13083

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Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration

C. Wang, X. Liu, S. Chen, F. Hu, J. Sun and H. Yuan, Chem. Commun., 2018, 54, 13080 DOI: 10.1039/C8CC07694D

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