Issue 26, 2018

Nickel-catalyzed cyanation of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine

Abstract

A nickel-catalyzed cyanation of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine (TCT) using aminoacetonitrile as the cyanating agent is described. This catalytic system delivered the desired products in moderate to good yields with good substrate compatibility. The readily available starting materials, cost-effective nickel catalyst and metal-free cyanating agent are the major features of the present method.

Graphical abstract: Nickel-catalyzed cyanation of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
03 May 2018
Accepted
11 Jun 2018
First published
12 Jun 2018

Org. Biomol. Chem., 2018,16, 4816-4820

Nickel-catalyzed cyanation of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine

L. Wang, Y. Wang, J. Shen, Q. Chen and M. He, Org. Biomol. Chem., 2018, 16, 4816 DOI: 10.1039/C8OB01034J

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