Issue 5, 2019

Metal-free tandem reaction synthesis of spiro-cyclopropyl fused pyrazolin-5-one derivatives

Abstract

A highly efficient cascade annulation approach was developed for the synthesis of novel spiro-cyclopropyl fused pyrazolin-5-ones from pyrazole-3-ketone substrates and two-component sulfur ylides in an acidic environment. This metal-free one-pot reaction has the advantages of easily available active materials, simple operation and brand new spirocyclic skeletons.

Graphical abstract: Metal-free tandem reaction synthesis of spiro-cyclopropyl fused pyrazolin-5-one derivatives

Associated articles

Supplementary files

Article information

Article type
Research Article
Submitted
20 Dec 2018
Accepted
21 Jan 2019
First published
21 Jan 2019

Org. Chem. Front., 2019,6, 664-668

Metal-free tandem reaction synthesis of spiro-cyclopropyl fused pyrazolin-5-one derivatives

M. Liu, C. Liu, J. Zhang, Y. Xu and L. Dong, Org. Chem. Front., 2019, 6, 664 DOI: 10.1039/C8QO01378K

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