Issue 7, 2020
From the journal:

Chemical Communications

The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter†

Satrialdi, ORCID logo ‡ab   Reina Munechika,a   Vasudevanpillai Biju, ORCID logo cd   Yuta Takano, ORCID logo cd   Hideyoshi Harashimaa  and  Yuma Yamada ORCID logo ‡*a  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan
E-mail: u-ma@pharm.hokudai.ac.jp

b School of Pharmacy, Institut Teknologi Bandung, Ganesha 10, Bandung 40132, Indonesia

c Research Institute for Electronic Science, Hokkaido University, Kita-20 Nishi-10, Kita-ku, Sapporo 001-0020, Japan
E-mail: tak@es.hokudai.ac.jp

d Graduate School of Environmental Science, Hokkaido University, Kita-10 Nishi-5, Kita-ku, Sapporo 060-0810, Japan

Abstract

The uncontrolled production of reactive oxygen species during photodynamic therapy (PDT) induces oxidative stress. The full potential of PDT is accomplished by delivery of a pi-extended porphyrin-type photosensitizer into mitochondria of tumor cells using a MITO-Porter, a mitochondrial targeting nanodevice. This strategy can be implemented for innovative cancer therapy.

Graphical abstract: The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter

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Article information

DOI
https://doi.org/10.1039/C9CC08563G
Article type
Communication
Submitted
02 Nov 2019
Accepted
13 Dec 2019
First published
16 Dec 2019

Chem. Commun., 2020,56, 1145-1148

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The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter

Satrialdi, R. Munechika, V. Biju, Y. Takano, H. Harashima and Y. Yamada, Chem. Commun., 2020, 56, 1145 DOI: 10.1039/C9CC08563G

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