Issue 42, 2020
From the journal:

Chemical Communications

GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy†

Yu Zhang,a   Wei Shen,b   Peng Zhang,bc   Li Chen ORCID logo *a  and  Chunsheng Xiao ORCID logo *bc  

* Corresponding authors

a Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun 130024, P. R. China
E-mail: chenl686@nenu.edu.cn

b Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
E-mail: xiaocs@ciac.ac.cn

c Jilin Biomedical Polymers Engineering Laboratory, Changchun, 130022, P. R. China

Abstract

Herein, a promising strategy is explored to regulate redox balance in tumor cells by simultaneously consuming GSH and releasing SO2 gas for enhanced photodynamic therapy. The photosensitizer is loaded with a carrier that releases SO2 gas in response to GSH overexpressed in the cell. SO2 was found not only to induce cell apoptosis but also increase the intercellular ROS level. Meanwhile, the loaded-photosensitizers could also generate ROS with light irradiation, resulting in apoptosis or necrosis of cells.

Graphical abstract: GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/D0CC00470G
Article type
Communication
Submitted
17 Jan 2020
Accepted
08 Apr 2020
First published
09 Apr 2020

Chem. Commun., 2020,56, 5645-5648

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GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy

Y. Zhang, W. Shen, P. Zhang, L. Chen and C. Xiao, Chem. Commun., 2020, 56, 5645 DOI: 10.1039/D0CC00470G

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