Iridium-catalyzed C–H amidation of s-tetrazines

Huan Xiong; Yuang Gu; Shuning Zhang; Fengping Lu; Qun Ji; Lili Liu; Peixiang Ma; Guang Yang; Wei Hou; Hongtao Xu

doi:10.1039/D0CC01647K

Iridium-catalyzed C–H amidation of s-tetrazines†

Huan Xiong,‡^a Yuang Gu,‡^abcd Shuning Zhang,^abcd Fengping Lu,^a Qun Ji,^a Lili Liu,^a Peixiang Ma,^a Guang Yang,^a Wei Hou

*^e and Hongtao Xu

*^a

Author affiliations

* Corresponding authors

^a Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China
E-mail: xuht@shanghaitech.edu.cn

^b School of Life Science and Technology, ShanghaiTech University, Shanghai, China

^c Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

^d University of Chinese Academy of Sciences, Beijing, China

^e College of Pharmaceutical Science, and Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, China
E-mail: houwei@ziut.edu.cn

Abstract

An efficient, selective and scalable C–H amidation of s-tetrazines under iridium(III) catalysis is reported. This reaction features a broad substrate scope, high functional group tolerance, and air and water tolerance. This reaction also shows great potential for the rapid preparation of tri- and tetra-functional building blocks, which can be applied either in bioconjugation or synthesis of DNA-encoded library.

Chemical Communications

Iridium-catalyzed C–H amidation of s-tetrazines†

Abstract

Associated articles

Supplementary files

Article information

Download Citation

Permissions

Iridium-catalyzed C–H amidation of s-tetrazines

Social activity

Search articles by author

Spotlight

Advertisements