Reply to the ‘Comment on “Investigation of Zr(IV) and 89Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging”’ by A. Bianchi and M. Savastano, Chem. Commun., 2020, 56, D0CC01189D

François Guérard; Yong-Sok Lee; Raphaël Tripier; Lawrence P. Szajek; Jeffrey R. Deschamps; Martin W. Brechbiel

doi:10.1039/D0CC03594G

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Reply to the ‘Comment on “Investigation of Zr(iv) and ⁸⁹Zr(iv) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging”’ by A. Bianchi and M. Savastano, Chem. Commun., 2020, 56, D0CC01189D

François Guérard,

*^a Yong-Sok Lee,

^b Raphaël Tripier,

*^c Lawrence P. Szajek,^d Jeffrey R. Deschamps^e and Martin W. Brechbiel

Author affiliations

* Corresponding authors

^a Université de Nantes, CNRS, Inserm, CRCINA, F-44000 Nantes, France
E-mail: francois.guerard@univ-nantes.fr

^b Center for Molecular Modeling, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA

^c Univ. Brest, UMR CNRS 6521 CEMCA, 6 Avenue Victor Le Gorgeu, Brest, France
E-mail: raphael.tripier@univ-brest.fr

^d Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA

^e Center for Bio/Molecular Science and Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, DC, USA

^f Center for Cancer Research, National Cancer Institute, Building 10, Room B3B69, Bethesda, MD 20892, USA

Abstract

The alternative analysis of A. Bianchi and M. Savastano is a valuable contribution to the understanding of the complex systems at stake in the complexation chemistry of Zr⁴⁺ by considering polynuclear species. Placed in the context of nuclear medicine where such aggregates are unlikely and considering recent literature data, this however points out that no clear agreement exists to describe such complex formation.

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Article information

DOI: https://doi.org/10.1039/D0CC03594G
Article type: Comment
Submitted: 20 May 2020
Accepted: 10 Sep 2020
First published: 18 Sep 2020

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Chem. Commun., 2020,56, 12667-12668

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Reply to the ‘Comment on “Investigation of Zr(IV) and ⁸⁹Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging”’ by A. Bianchi and M. Savastano, Chem. Commun., 2020, 56, D0CC01189D

F. Guérard, Y. Lee, R. Tripier, L. P. Szajek, J. R. Deschamps and M. W. Brechbiel, Chem. Commun., 2020, 56, 12667 DOI: 10.1039/D0CC03594G

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