An efficient asymmetric aza-Friedel–Crafts reaction of phenols with isatin-derived ketimines is described. The reaction, which was promoted by a Bi(OH)3/CPA system, gave a series of chiral 3-amino-2-oxindoles with high yields (up to 99%), excellent enantioselectivities (up to 99%) and moderate to very good regioselectivities (up to 25/1).
L. Cai, X. Liu, J. Wang, L. Chen, X. Li and J. Cheng, Chem. Commun., 2020, 56, 10361 DOI: 10.1039/D0CC04966B
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