Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer

Ziwei Li; Fan Yang; Di Wu; Yanhong Liu; Yang Gao; Haichen Lian; Hongxin Zhang; Zhibin Yin; Aiguo Wu; Leyong Zeng

doi:10.1039/D0NR05386D

Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer†

Ziwei Li,^a Fan Yang,^b Di Wu,*^a Yanhong Liu,^a Yang Gao,^a Haichen Lian,^b Hongxin Zhang,^b Zhibin Yin,^a Aiguo Wu

*^c and Leyong Zeng

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, College of Chemistry & Environmental Science, Institute of Life Science and Green Development, Hebei University, Baoding 071002, P.R. China
E-mail: zengly@hbu.cn, wudi2137@126.com

^b Medical Department & Affiliated Hospital of Hebei University, Baoding 071002, P.R. China

^c Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, P.R. China
E-mail: aiguo@nimte.ac.cn

Abstract

Metastasis is the main cause of treatment failure in breast cancer, and integrated phototheranostics is a promising strategy to achieve both precision theranostics and metastasis inhibition. In this work, a multifunctional phototheranostic nanoprobe composed of chlorin e6 (Ce6)-conjugated and polydopamine (PDA)-coated gold nanostars (AuNSs) was synthesized for simultaneous photoacoustic (PA) imaging, photothermal therapy (PTT) and photodynamic therapy (PDT). Under the irradiation of near infrared laser, AuNSs@PDA showed enhanced photothermal conversion and amplified PA imaging performance, compared with single AuNSs. By the covalent conjugation of Ce6, the AuNSs@PDA-Ce6 nanoprobe showed robust stability and excellent singlet oxygen (¹O₂) generation ability. Under the combination of PTT/PDT, the AuNSs@PDA-Ce6 nanoprobes significantly reduced the growth of 4T1 tumors and suppressed their lung metastasis. All the results demonstrated the considerable potential of AuNSs@PDA-Ce6 phototheranostic nanoprobes for precision theranostics and metastasis inhibition of breast cancer.

Nanoscale

Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer†

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Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer

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