Regioselective synthesis of substituted thiazoles via cascade reactions from 3-chlorochromones and thioamides†
Chunhao
Yang 
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Abstract
A facile and efficient strategy to synthesize substituted thiazoles via a cascade reaction from chromone derivatives and thioamides in an environmentally benign medium was developed. This cascade reaction involves a Michael addition/intramolecular cyclization process and a broad scope of reversed regioselectivity products was prepared in a short reaction time with excellent yields. The reversed regioselectivity was also explained by DFT calculations.
- This article is part of the themed collection: Synthetic methodology in OBC
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