A sensitive OFF–ON–OFF fluorescent probe for the cascade sensing of Al3+ and F− ions in aqueous media and living cells

Lingjie Hou; Wenting Liang; Chenhua Deng; Caifeng Zhang; Bo Liu; Shaomin Shuang; Yu Wang

doi:10.1039/D0RA02848G

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A sensitive OFF–ON–OFF fluorescent probe for the cascade sensing of Al³⁺ and F⁻ ions in aqueous media and living cells†

Lingjie Hou,^ac Wenting Liang,

*^b Chenhua Deng,^ac Caifeng Zhang,^ac Bo Liu,^d Shaomin Shuang

^b and Yu Wang

*^b

Author affiliations

* Corresponding authors

^a Department of Chemistry, Taiyuan Normal University, Jinzhong 030619, P. R. China

^b Department of Chemistry, Institute of Environmental Science, Shanxi University, Taiyuan 030006, P. R. China
E-mail: liangwt@sxu.edu.cn, wangyu1168@sxu.edu.cn

^c Humic Acid Engineering and Technology Research Center of Shanxi Province, Jinzhong 030619, P. R. China

^d National Institutes for Food and Drug Control, Beijing 100050, P. R. of China

Abstract

A simple Schiff-base ligand 2-hydroxy-1-naphthaldehyde semicarbazone (HNS) was synthesized and characterized. Based on the combined effect of inhibition of CH [double bond, length as m-dash] N isomerization and chelation-enhanced fluorescence (CHEF), HNS functions as a fluorescence “turn on” sensor for Al³⁺ in buffered aqueous media. Based on the strong affinity of Al³⁺ to F⁻ ions, the in situ generated Al³⁺–HNS complex can also be utilized as an effective chemosensor for F⁻ sensing by metal displacement approach, ensuing quenching of fluorescence by the reversible return of HNS from Al³⁺–HNS complex. Thus a method using a single probe for the detection of both Al³⁺ and F⁻ ions is developed. The system exhibits high selectivity and sensitivity for Al³⁺ and F⁻ ions and the detection limits were found to be as low as 6.75 × 10⁻⁸ M and 7.89 × 10⁻⁷ M, respectively. Furthermore, the practical applicability of this probe has been examined in living cells.

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Article information

DOI: https://doi.org/10.1039/D0RA02848G
Article type: Paper
Submitted: 28 Mar 2020
Accepted: 26 May 2020
First published: 05 Jun 2020
This article is Open Access

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RSC Adv., 2020,10, 21629-21635

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A sensitive OFF–ON–OFF fluorescent probe for the cascade sensing of Al³⁺ and F⁻ ions in aqueous media and living cells

L. Hou, W. Liang, C. Deng, C. Zhang, B. Liu, S. Shuang and Y. Wang, RSC Adv., 2020, 10, 21629 DOI: 10.1039/D0RA02848G

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