Issue 39, 2020
From the journal:

RSC Advances

Metal-free oxidative coupling of arylmethylamines with indoles: a simple, environmentally benign approach for the synthesis of 3,3′-bis(indolyl)methanes†

Vikas D. Kadu, ORCID logo *a   Sankala Naga Chandrudu, ORCID logo b   Mahesh G. Hublikar, ORCID logo a   Dattatraya G. Rauta  and  Raghunath B. Bhosalea  

* Corresponding authors

a School of Chemical Sciences, Punyashlok Ahilyadevi Holkar Solapur University, Solapur-413255, Maharashtra, India
E-mail: vikaskadu1@gmail.com

b Department of Chemistry, College of Engineering, Rayalseema University, Kurnool-518002, Andhra Pradesh, India

Abstract

The efficient metal-free oxidative coupling of arylmethylamines with indoles has been developed using molecular oxygen as a green oxidant. The present reaction provides a novel route towards the synthesis of 3,3′-bis(indolyl)methanes in excellent yields of up to 95% via C–C and C–N bond formation. This attractive and environmentally friendly one-pot protocol is a simple procedure that features inexpensive acetic acid as the catalyst and molecular oxygen as the sole oxidant, and it supports a wide substrate scope with the good tolerance of functional groups.

Graphical abstract: Metal-free oxidative coupling of arylmethylamines with indoles: a simple, environmentally benign approach for the synthesis of 3,3′-bis(indolyl)methanes

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Article information

DOI
https://doi.org/10.1039/D0RA03221B
Article type
Paper
Submitted
10 Apr 2020
Accepted
25 May 2020
First published
17 Jun 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 23254-23262

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Metal-free oxidative coupling of arylmethylamines with indoles: a simple, environmentally benign approach for the synthesis of 3,3′-bis(indolyl)methanes

V. D. Kadu, S. N. Chandrudu, M. G. Hublikar, D. G. Raut and R. B. Bhosale, RSC Adv., 2020, 10, 23254 DOI: 10.1039/D0RA03221B

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