Issue 39, 2021
From the journal:

Chemical Communications

Co-self-assembly of multiple DNA origami nanostructures in a single pot†

Joshua A. Johnson,a   Vasiliki Kolliopoulosb  and  Carlos E. Castro ORCID logo *ac  

* Corresponding authors

a Biophysics Graduate Program, The Ohio State University, 281 W Lane Ave, Columbus, OH 43210, USA
E-mail: castro.39@osu.edu

b Department of Chemical and Biomolecular Engineering, The Ohio State University, 281 W Lane Ave, Columbus, OH 43210, USA

c Department of Mechanical and Aerospace Engineering, The Ohio State University, 281 W Lane Ave, Columbus, OH 43210, USA

Abstract

Simultaneous self-assembly of two distinct DNA origami nanostructures folded with the same scaffold strand was achieved in a single pot. Relative yields were tuned by adjusting concentrations of the competing strands, correlating well with folding kinetics of individual structures. These results can faciliate efficient fabrication of multi-structure systems and materials.

Graphical abstract: Co-self-assembly of multiple DNA origami nanostructures in a single pot

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Article information

DOI
https://doi.org/10.1039/D1CC00049G
Article type
Communication
Submitted
04 Jan 2021
Accepted
11 Mar 2021
First published
15 Apr 2021
This article is Open Access
Creative Commons BY license

Chem. Commun., 2021,57, 4795-4798

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Co-self-assembly of multiple DNA origami nanostructures in a single pot

J. A. Johnson, V. Kolliopoulos and C. E. Castro, Chem. Commun., 2021, 57, 4795 DOI: 10.1039/D1CC00049G

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