Issue 90, 2021
From the journal:

Chemical Communications

Synthesis, self-aggregation and cryopreservation effects of perylene bisimide–glycopeptide conjugates†

Xu He,‡ab   Bing Hu,‡ab   Yan Yang,bc   Hong-Yu Zhu,ab   Rui-Xue Rong,bc   Xiao-Liu Li*ab  and  Ke-Rang Wang ORCID logo *ab  

* Corresponding authors

a College of Chemistry and Environmental Science, Hebei University, Baoding, P. R. China
E-mail: kerangwang@hbu.edu.cn, lixl@hbu.cn

b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Hebei University), Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, P. R. China

c Department of Immunology, School of Basic Medical Science, Hebei University, Baoding 071002, P. R. China

Abstract

Three perylene bisimide–glycopeptide conjugates (PBI-AFF-Man, PBI-AFF-Glu and PBI-AFF-Gal) were synthesized, which showed moderate activity in the control of ice crystal growth. Furthermore, the cellular cryopreservation effects of PBI-AFF-Man, PBI-AFF-Glu and PBI-AFF-Gal showed enhancements in cell viabilities, especially for PBI-AFF-Glu with values of 22.77 ± 3.33% (HeLa cells), 19.43 ± 1.90% (A549 cells) and 16.63 ± 1.76% (GES-1 cells) at a dose of 1.0 mg mL−1. This work will help guide the development of self-assembled cryoprotectants.

Graphical abstract: Synthesis, self-aggregation and cryopreservation effects of perylene bisimide–glycopeptide conjugates

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Article information

DOI
https://doi.org/10.1039/D1CC03835D
Article type
Communication
Submitted
15 Jul 2021
Accepted
19 Oct 2021
First published
20 Oct 2021

Chem. Commun., 2021,57, 12000-12003

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Synthesis, self-aggregation and cryopreservation effects of perylene bisimide–glycopeptide conjugates

X. He, B. Hu, Y. Yang, H. Zhu, R. Rong, X. Li and K. Wang, Chem. Commun., 2021, 57, 12000 DOI: 10.1039/D1CC03835D

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