* Corresponding authors

^a Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences Henan University Kaifeng, Henan 475004, China
E-mail: mzheng@henu.edu.cn, bs@henu.edu.cn

^b Department of Clinical Laboratory, Kaifeng Central Hospital, No. 85, Hedao Street, Kaifeng, Henan, China

^c State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing 210023, China

^d Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, Australia

^e Department of Molecular Sciences, Faculty of Science and Engineering, Macquarie University, Sydney 2109, Australia
E-mail: yuling.wang@mq.edu.au