Polymerase-mediated synthesis of p-vinylaniline-coupled fluorescent DNA for the sensing of nucleolin protein–c-myc G-quadruplex interactions†
Abstract
In this paper we report the synthesis of two deoxyuridine derivatives (dUCN2, dUPy)—featuring p-vinylaniline-based fluorophores linked through a propargyl unit at the 5′ position—that function as molecular rotors. This probing system proved to be useful for the sensing of gene regulation arising from interactions between this G-quadruplex and nucleolin.
- This article is part of the themed collection: Chemical Biology in OBC
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