Cyclic phosphatidic acids (cPAs) are bioactive compounds with therapuetic potential, but are in short supply. We describe a robust synthesis of cPAs employing an efficient cyclophosphorylation procedure and report on their hydrolytic properties – which should facilitate the study of their biological properties and as plausible proto- and synthetic-cell components.
V. E. Ortuno, S. Pulletikurti, K. S. Veena and R. Krishnamurthy, Chem. Commun., 2022, 58, 6231 DOI: 10.1039/D2CC00292B
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