Visible light-assisted Ni-/Ir-catalysed atom-economic synthesis of spiro[furan-3,1′-indene] derivatives†
Abstract
An atom-economic, efficient, and highly convenient construction of spiro[furan-3,1′-indene] skeletons from isocyanides and 1,5-enynes by synergistic nickel- and iridium-photocatalysis is reported. Spirocyclization was developed under practical and mild conditions, which features excellent functional group tolerance, gram-scale synthesis and representative synthetic transformations for the obtained products and broad substrate scope. Primary mechanistic studies demonstrated that the reaction proceeds through energy-transfer-mediated excitation of intermediate catalytic species.
![Graphical abstract: Visible light-assisted Ni-/Ir-catalysed atom-economic synthesis of spiro[furan-3,1′-indene] derivatives](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D2CC00717G&imageInfo.ImageIdentifier.Year=2022)
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