Copper coordination-based conjugated polymer nanoparticles for synergistic photodynamic and chemodynamic therapy

Qiang Cheng; Yuyan Li; Wei Huang; Ke Li; Minhuan Lan; Benhua Wang; Jianxiu Wang; Xiangzhi Song

doi:10.1039/D3CC01107K

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Copper coordination-based conjugated polymer nanoparticles for synergistic photodynamic and chemodynamic therapy†

Qiang Cheng,^a Yuyan Li,^a Wei Huang,

^b Ke Li,^a Minhuan Lan,

^a Benhua Wang,

*^a Jianxiu Wang

*^a and Xiangzhi Song

Author affiliations

* Corresponding authors

^a College of Chemistry & Chemical Engineering, Central South University, Changsha, Hunan 410083, China
E-mail: benhuawang@csu.edu.cn, jxiuwang@csu.edu.cn

^b School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, China

Abstract

In this work, we presented a copper coordination-based conjugated polymer nanoparticle (PPE-Cu NPs) for synergistic PDT/CDT. Upon irradiation, PPE-Cu NPs exhibited good singlet oxygen generation capability (Φ_Δ = 0.33). Meanwhile, PPE-Cu NPs were able to generate ˙OH in the presence of GSH and H₂O₂. Cellular experiments demonstrated that PPE-Cu NPs can serve as effective agents for synergistic PDT/CDT therapy.

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Article information

DOI: https://doi.org/10.1039/D3CC01107K
Article type: Communication
Submitted: 06 Mar 2023
Accepted: 20 Apr 2023
First published: 21 Apr 2023

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Chem. Commun., 2023,59, 5886-5889

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Copper coordination-based conjugated polymer nanoparticles for synergistic photodynamic and chemodynamic therapy

Q. Cheng, Y. Li, W. Huang, K. Li, M. Lan, B. Wang, J. Wang and X. Song, Chem. Commun., 2023, 59, 5886 DOI: 10.1039/D3CC01107K

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Chemical Communications

Copper coordination-based conjugated polymer nanoparticles for synergistic photodynamic and chemodynamic therapy†

Abstract

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Supplementary files

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Copper coordination-based conjugated polymer nanoparticles for synergistic photodynamic and chemodynamic therapy

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