Issue 20, 2023

Alkyl radicals from diacyl peroxides: metal-/base-/additive-free photocatalytic alkylation of N-heteroaromatics

Abstract

Alkyl diacyl peroxides were demonstrated to be efficient alkylating reagents for the visible-light-induced 4CzIPN-catalyzed direct C–H alkylation of N-heteroaromatics. With this metal-/base-/additive-free photocatalytic system, 57 examples of alkylated N-heteroaromatics scaffolds including 1,2,4-triazine-3,5(2H,4H)-diones (i.e. azauracils), quinoxalin-2(1H)-ones, 2H-benzo[b][1,4]oxazin-2-ones and quinoxalines were successfully synthesized.

Graphical abstract: Alkyl radicals from diacyl peroxides: metal-/base-/additive-free photocatalytic alkylation of N-heteroaromatics

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
13 Jul 2023
Accepted
26 Sep 2023
First published
28 Sep 2023

Green Chem., 2023,25, 7971-7977

Alkyl radicals from diacyl peroxides: metal-/base-/additive-free photocatalytic alkylation of N-heteroaromatics

F. Cheng, L. Fan, Q. Lv, X. Chen and B. Yu, Green Chem., 2023, 25, 7971 DOI: 10.1039/D3GC02545D

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