* Corresponding authors

^a School of Medicine, China Medical University, Taichung 406040, Taiwan

^b Department of Orthopedic Surgery, China Medical University Hospital, Taichung 404332, Taiwan

^c x-Dimension Center for Medical Research and Translation, China Medical University Hospital, Taichung 404332, Taiwan
E-mail: eric@mail.cmu.edu.tw

^d Graduate Institute of Biomedical Sciences, China Medical University, Taichung 406040, Taiwan

^e School of Dentistry, China Medical University, Taichung 406040, Taiwan

^f Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan