A new heterocyclisation reaction leading to cinnolin-4(1H)-one derivatives
Abstract
2-Nitrophenacylidene phenylhydrazones (2) undergo base-catalysed cyclisation by intramolecular nucleophilic displacement of the nitro-group by the ortho-side-chain, providing an efficient general route to 3-substituted 1-phenylcinnolin-4(1H)-ones (3).