Issue 3, 1977

Synthesis of oligopeptides having alternate L-leucyl and L-methionyl residues

Abstract

A series of oligopeptides having alternate L-leucyl and L-methionyl residues which are interesting from a conform-ational aspect have been prepared by a method involving use of an N-o-nitrophenylsulphenyl-N-carboxy-α-amino-acid anhydride (Nps-NCA). The peptides were assembled stepwise, with L-methionine ethyl ester as the starting amino-acid; L-leucyl residues were introduced in high yields by the ‘Nps-NCA’ method, and L-methionyl residues in moderate yields by the dicyclohexylcarbodi-imide method. The usefulness of the Nps-NCA method for peptide synthesis is demonstrated.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1977, 292-294

Synthesis of oligopeptides having alternate L-leucyl and L-methionyl residues

R. Katakai and Y. Nakayama, J. Chem. Soc., Perkin Trans. 1, 1977, 292 DOI: 10.1039/P19770000292

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements