In sharp contrast to prior observations that 2-lithio-1,3-dithians undergo only carbonyl (1,2–) additions to enones, the successful conjugate (1,4–) addition of the parent 2-lithio-1,3-dithian and its simple derivatives has been achieved by the addition of 1·0–2·0 equiv. of hexamethylphosphoramide to the reaction mixture.
C. A. Brown and A. Yamaichi, J. Chem. Soc., Chem. Commun., 1979, 100 DOI: 10.1039/C39790000100
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