The C2-ketone rule in Horse liver alcohol dehydrogenase (HLADH)-catalysed oxidation and reduction
Abstract
The enantiomer selectivity of HLADH with respect to the racemic C2-ketone substrates (1), (3), (5), and (7) has been examined, showing that the enzyme exhibits a remarkable selectivity which is opposite to that indicated by the microbial C2-ketone rule for Curvularia lunata and Rhodotorula rubra.