Enantioselective 1,5-electrocyclization. Synthesis of optically active indolines
Abstract
Intramolecular base-catalysed 1,5-elecctrocyclization of aldehyde imines derived from o-aminophenyl succinimide (3) in the presence of a chiral alcohol yields chiral indolines (4) with optical purities ranging from 17 to 31%.