Issue 19, 1983

Two exceptional lithiations in the chromone series

Abstract

With lithium di-isopropylamide in tetrahydrofuran at –70 °C followed by pivaloyl chloride the 2-pivaloylmethyl-3-methoxymethylchromone (1) affords by a novel aromatic substitution the 8-pivaloylchromone (3); lithiation of the 2-(2-furyl)chromone (7) with one mol. Equiv. of the reagent followed by carbonation leads not to monocarboxylic acids but to a 50% yield of the dicarboxylic acid (8).

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1983, 1098-1099

Two exceptional lithiations in the chromone series

A. M. B. S. R. C. S. Costa, F. M. Dean, M. A. Jones and D. A. Smith, J. Chem. Soc., Chem. Commun., 1983, 1098 DOI: 10.1039/C39830001098

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