Studies with stable isotopes show that D-ribose and L-glutamic acid are direct biosynthetic precursors of showdomycin (1), with carbons 2–5 and the nitrogen of L-glutamate giving rise to the maleimide ring: L-pyroglutamate may be an intermediate.
J. G. Buchanan, M. R. Hamblin, A. Kumar and R. H. Wightman, J. Chem. Soc., Chem. Commun., 1984, 1515 DOI: 10.1039/C39840001515
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