The biosynthesis of the polyketide metabolite palitantin from deuterium and oxygen labelled acetates in Penicillium brefeldianum
Abstract
Isotopic shifts in the 13C n.m.r. spectrum of the polyketide metabolite palitantin labelled by incorporation 2H and 18O labelled acetates establish that no aromatic intermediates are involved in the generation of the six-membered carbocyclic ring.