Issue 8, 1987
From the journal:

Journal of the Chemical Society, Chemical Communications

Novel approach to the synthesis of isotopomeric monoalkyl [16O,17O,18O]phosphates. The stereospecific one-pot conversion of (RP)-thymidine 3′-(4-nitrophenyl)phosphorothioate into (RP)-thymidine 3′-[16O,17O,18O]phosphate

Andrzej Okruszek,   Piotr Guga  and  Wojciech J. Stec  

Abstract

Reaction of the (Rp)-diastereoisomer of thymidine 3′-(4-nitrophenyl)phosphorothioate with styrene [18O]oxide in a medium containing [17O]water gives (Rp)-thymidine [16O,17O,18O]phosphate in 70% yield with diastereoisotopomeric purity not lower than 92%.

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Article information

DOI
https://doi.org/10.1039/C39870000594
Article type
Paper

J. Chem. Soc., Chem. Commun., 1987, 594-595

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Novel approach to the synthesis of isotopomeric monoalkyl [16O,17O,18O]phosphates. The stereospecific one-pot conversion of (RP)-thymidine 3′-(4-nitrophenyl)phosphorothioate into (RP)-thymidine 3′-[16O,17O,18O]phosphate

A. Okruszek, P. Guga and W. J. Stec, J. Chem. Soc., Chem. Commun., 1987, 594 DOI: 10.1039/C39870000594

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