A series of structural variants of the cysteinyl moiety of the natural precursor of penicillins, δ(L-α-aminoadipoyl)-L-cysteinyl-D-valine, have been synthesised and their effectiveness as substrates for the enzyme isopenicillin N synthetase has been evaluated.
J. E. Baldwin, R. M. Adlington, N. Moss and N. G. Robinson, J. Chem. Soc., Chem. Commun., 1987, 1664 DOI: 10.1039/C39870001664
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