A new, concise approach to retinoid synthesis is described based on organometallic addition to pyrylium salts; the use of 4-methylpyrylium tetrafluoroborate giving 13Z-retinal which is readily isomerised to retinal itself; the corresponding unsubstituted and 4-cyclohexyl pyrylium salts are transformed into 13-H and 13-cyclohexyl retinal analogues.
K. Hemming, E. F. De Medeiros and R. J. K. Taylor, J. Chem. Soc., Chem. Commun., 1994, 2623 DOI: 10.1039/C39940002623
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