Amino Acids and Peptides. Part 48.1 Studies on the Structure of an Unexpected Reaction Product from Dipeptidyl Chloromethyl Ketone during Acid Hydrolysis 2

Abstract

During the course of the synthesis of peptidyl chloromethyl ketones (CMKs), it was revealed that amino acid recovery after acid hydrolysis (6 mol dm ^-3 HCl, 110 °C, 20 h) of dipeptidyl chloromethyl ketones was markedly low (7.1–33.7%) owing to the formation of 5-methylpyrazin-2(1H)-one derivatives during the acid hydrolysis.