Radical cyclisation with high diastereofacial selectivity: asymmetric synthesis of (+)-12b-epidevinylantirhine

Abstract

Radical cyclisation of the chiral α,β-unsaturated ester 1, carried out in the presence of MAD, gives six-membered cyclic acetal 2 diastereoselectively, which is transformed into (+)-12b-epidevinylantirhine 7.