Tropic acid biosynthesis: the incorporation of (RS)-phenyl[2-18O,2-2H]lactate into littorine and hyoscyamine in Datura stramonium
Abstract
The incorporation of oxygen-18 from (RS)-phenyl- [2-18O,2-2H]lactate into the tropane alkaloids littorine 1 and hyoscyamine 2 in Datura stramonium reveals that up to 29% of the oxygen-18 is lost during the transformation of 1 to 2.