2-D NMR Spectroscopy of chiral phosphine complexes. Applications to problems related to enantioselective homogeneous catalysis

Abstract

A 2-D NMR approach to elucidating problems of structure and dynamics in chiral organometalic phosphine complexes has been suggested. The examples chosen concern geometric isomers and prochiral face selection in ally derivatives, a new bonding mode for atropisomeric chelates, chelate ring inversion, phenyl stacking, detecting small quantities of exchanging species and recognising equlibrating diastereomers. The methodology, which is based on X,¹H correlation and NOE spectroscopy, is shown to be both versatile and potent.