Issue 2, 1999

Total synthesis of (+)-pramanicin and stereochemical elucidation of the natural product

Abstract

Total synthesis of (+)-pramanicin is achieved through a ‘one pot’ Michael addition of an aminosilyl zincate species to an α,β-unsaturated lactam and quenching of the resultant enolate with an α,β-unsaturated γ,δ-epoxy aldehyde.

Article information

Article type
Paper

Chem. Commun., 1999, 133-134

Total synthesis of (+)-pramanicin and stereochemical elucidation of the natural product

A. G. M. Barrett, M. L. Smith and N. S. Stock, Chem. Commun., 1999, 133 DOI: 10.1039/A807988I

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